How Much Benadryl to Give a Dog? Comprehensive Chart

Benadryl is a widely used medication for humans but is also safe to use for dogs. However, since it’s made for humans, it’s not always easy to figure out the correct dose of Benadryl for dogs

This is why we’ve created a Benadryl dosage chart for dogs, covering all the uses, safety measures, and side effects you can expect. 

So, be sure to read more.

How Much Benadryl To Give a Dog?

A normal Benadryl dosage for dogs is between 0.9 to 1.8 milligrams of Benadryl for each pound of weight. For liquid Benadryl, you should use 0.4 ml per pound of weight. 

You shouldn’t give them more than two to three doses a day.

(WebMD, 2021, Omni Calculator, 2021)

Benadryl for Dogs Dosage by Weight — Comprehensive Chart

(Omni Calculator, 2021)

The right dose for your dog depends on its weight. For example, a 5 lb dog will need 5 mg of Benadryl, while a 15 lb dog will need 15 mg. Also, Benadryl tablets differ from liquid Benadryl, so dosages will be different.

To find the right Benadryl dose for dogs, check out our chart:

Weight  Benadryl Tablets Liquid Benadryl
10lbs 10mg 4ml
20lbs 20mg 8ml
30lbs 30mg 12ml
40lbs 40mg 16ml
50lbs 50mg 20ml
60lbs 60mg 24ml
70lbs 70mg 28ml
80lbs 80mg 32ml
90lbs 90mg 36ml
100lbs 100mg 38ml

Also, be aware that measuring the best Benadryl dose for a dog is much easier with liquid Benadryl. Benadryl tablets contain 25 mg per tablet and might be a bit more difficult to dose.

If you have a small dog, using children’s Benadryl can help you get the right dosage more easily. 

Benadryl for Dogs — Everything You Should Know 

Read on to find out what Benadryl can be used for, what side effects it can have, and what you should pay attention to when buying Benadryl for your dog.

Benadryl is mainly used as an antihistamine for dogs.

(VCA Animal Hospitals, 2021, MedicalNewsToday, 2021)

It’s likely to work well on your dog, but a recent study has found that cetirizine might work better for calming dogs’ allergies. This is why you should always consult your vet if your dog has allergies.

Benadryl can be used for other dog-related illnesses:

  • Itching — Benadryl has calming properties and is the first treatment used in itchiness caused by hives.
  • Nausea — it stops vomiting and helps with motion sickness.
  • Vestibular disease —  You can use Benadryl for vestibular disease to help with vomiting, but some new medications were proven to work better.

Adult liquid Benadryl can be harmful to dogs.

(Veterinary Partner, 2021)

Liquid Benadryl for adults contains alcohol, and alcohol is extremely harmful to dogs. If you prefer using liquid Benadryl, children’s Benadryl is a lot safer for dogs because it’s alcohol-free.

In general, when buying Benadryl, focus on the options containing only diphenhydramine with no extra ingredients.

Drowsiness is one of the most common side effects of Benadryl in dogs.

(PetMD, 2020)

However, this can be useful if your dog has trouble sleeping. So, you can use Benadryl to calm your dog.

Also, you can use Benadryl for dogsanxiety in emergencies. It’s also useful for stressful situations, such as grooming.

Just keep in mind that the effects are not long-lasting, and there are better ways of relieving anxiety, such as prescription medicine, natural CBD-induced oil, noise machines, and similar.

There are a few common side effects of Benadryl.

(American Kennel Club, )

Besides getting drowsy, your dog can also experience these symptoms when using Benadryl:

  • Dry mouth
  • Constipation
  • Difficulty with urination
  • Fast breathing

Your dog might also experience diarrhea, vomiting, and have changes in appetite as a side effect of Benadryl. However, these are much rarer. 

Some dogs might even get more anxious or aggressive, but this usually happens when they overdose. So, make sure to consult your vet about changing their medication and not give them more Benadryl than necessary.


Using Benadryl for dogs is safe — but only when done right. So, if you have an allergic dog, our Benadryl dosage chart should help you get a grasp of how much Benadryl your dog should take. However, if you have any questions, always consult your vet.


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